Astrocyte Reactivity Regulation Browser

Astrocyte Reactivity
Regulation Browser

Condition ID Condition Description Species Experimental Design and Astrocyte RNA Isolation Source Data Analysis Platform Reference
EAE Autoimmune neuroinflammation Mouse EAE, 45 dpi (MOG35-55). Ribosome-associated mRNA isolation from lower thoracic spinal cord of 2-4 month-old mGFAP-Cre:RiboTag mice. GSE100330 RNA-seq Itoh et al. (2018); PMID: 29279367
SCI Traumatic spinal cord injury Mouse SCI (14 dpi). Ribosome-associated mRNA isolation from lower thoracic spinal cord lesion epicenter and astrocyte scar 2-4 month-old mGFAP-Cre:RiboTag mice. NCBI GEO: GSE76097 RNA-seq Anderson et al. (2016); PMID: 27027288
LPSsc LPS-induced neuroinflammation (spinal cord) Mouse 24 hour systemic LPS. Ribosome-associated mRNA isolation from lower thoracic spinal cord of 2-4 month-old mGFAP-Cre:RiboTag mice. Present Study RNA-seq -
LPSBR LPS-induced neuroinflammation (brain) Mouse 24 hour systemic LPS. Total RNA from acutely isolated murine astrocytes from P30-35 Aldh1l1-eGFP mouse whole brain hemisphere. NCBI GEO: GSE35338 Microarray (mouse) Zamanian et al (2012); PMID: 22553043
MCAO1 Ischemic-reperfusion injury (MCAO) - 1 dpi Mouse MCAO (1 dpi). Total RNA from acutely isolated murine astrocytes from P30-35 Aldh1l1-eGFP mouse whole brain hemisphere. NCBI GEO: GSE35338 Microarray (mouse) Zamanian et al (2012); PMID: 22553043
MCAO7 Ischemic-reperfusion injury (MCAO) - 7 dpi Mouse MCAO (7 dpi). Total RNA from acutely isolated murine astrocytes from P30-35 Aldh1l1-eGFP mouse whole brain hemisphere. NCBI GEO: GSE35338 Microarray (mouse) Zamanian et al (2012); PMID: 22553043
EpiH Epilepsy Human 59-64 year-old patients vs matched controls. Total RNA from immuno-panned astrocytes isolated from sclerotic hippocampal specimens involved in epileptic foci. NCBI GEO: GSE73721 RNA-seq Zhang et al (2016); PMID: 26687838
GBMH Glioma Human 21-53 year-old patients vs matched controls. Total RNA from immuno-panned astrocytes isolated from cortical specimens from glioblastoma core and peripheral regions NCBI GEO: GSE73721 RNA-seq Zhang et al (2016); PMID: 26687838
ALSM Amyotrophic lateral sclerosis. (SOD1-G37R model) Mouse Disease onset (~8 months of age); Ribosome-associated mRNA isolation from spinal cord of Aldh1l1-Cre:BacTRAP mouse NCBI GEO: GSE74724 RNA-seq Sun et al (2015); PMID: 26621731
HDR6/2 Huntington’s disease R6/2 model Mouse 3 month-old HD R6/2 mice. Ribosome-associated mRNA isolation from striatal astrocytes following viral transduction by AAV2/5 RiboTag construct. NCBI GEO: GSE124846 RNA-seq Diaz-Castro et al (2019); PMID: 31619545
HDQ175 Huntington’s disease Q175 model Mouse 12 month-old HD Q175 mice. Ribosome-associated mRNA isolation from striatal astrocytes following viral transduction by AAV2/5 RiboTag construct. NCBI GEO: GSE124846 RNA-seq Diaz-Castro et al (2019); PMID: 31619545
ADAPOE4 Alzhiemers disease Human 78-93 year-old patients. APOE staus: 3/3 or 3/4, Braak stage range: IV-VI. Laser capture microdissection of cells immunoreactive to anti-ALDH1L1 antibody. dbGaP: phs000745.v1.p1 RNA-seq Sekar et al (2016); PMID 25448601
ADM Alzhiemers disease (APPswe/PS1dE9 model) Mouse Chronic disease (15 months old). Total RNA isolated from FACS of Glt1- positive mouse cortical astrocytes. NCBI GEO: GSE74614 RNA-seq Kamphuis et al (2015); PMID: PMC5783200
AgedMC Aged motor cortex Mouse 2 year-old (aged). Ribosome-associated mRNA isolation from mGFAPCre: RiboTag mouse cortex. NCBI GEO: GSE99791 RNA-seq Boisvert et al (2017); PMID: 29298427
AgedCB Aged cerebellum Mouse 2 year-old (aged). Ribosome-associated mRNA isolation from mGFAPCre: RiboTag mouse cerebellum. NCBI GEO: GSE99791 RNA-seq Boisvert et al (2017); PMID: 29298427
Hthy Healthy CNS (spinal cord) Mouse 2-4 months-old. Ribosome-associated mRNA isolation from lower thoracic spinal cord of healthy, 2-4 month-old mGFAP-Cre:RiboTag mice. Present Study RNA-seq -
Disorders with WT astrocytes
Diseases with mutations & polymorphisms
Aging
Healthy